414 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study reveals that mitochondrial protein import, specifically via the TIM23-PAM axis, acts as a critical link between proteostasis failure and mitochondrial injury, driving intrinsic apoptosis independently of canonical BCL-2 family pore-forming proteins.
This study demonstrates that the chorioallantoic membrane (CAM) model is a valuable platform for analyzing the cell cycle dynamics of xenografted pancreatic ductal adenocarcinoma (PDAC) cells, while also revealing a previously unidentified confounding phenomenon where non-proliferating chicken cells accumulate synthetic nucleosides in their cytoplasm after embryonic day 14.
This study identifies inorganic polyphosphate as a structural scaffold for filopodia that stabilizes cell adhesion by recruiting IRSp53, and demonstrates that restoring reduced polyP levels in cancer cells suppresses invasion and reverses metastatic gene signatures, implicating it as a primordial tumor suppressor.
This study demonstrates that the loss of PKN2 drives fibroblast reprogramming and aberrant extracellular matrix remodelling in pulmonary fibrosis by dysregulating key pathways such as non-canonical WNT and VEGF, thereby impairing tissue repair.
This study reports the successful generation and comprehensive characterization of a patient-specific human induced pluripotent stem cell line (ASCFi003-A) derived from a Skogholt syndrome patient, which retains the disease-associated genetic variant and serves as a valuable resource for modeling the disorder through choroid plexus organoids and neurons.
This study reveals that PIKfyve inhibition activates LRRK2 signaling at lysosomes through a ClC-7-dependent pathway that accumulates Rab GTPases, distinguishing it from other stress responses that require both Rab-binding sites and GABARAP.
This study demonstrates that a self-organized signaling hierarchy, driven by the recruitment of proteins like p190RhoGAP to the overlapping interface of Rho and Cdc42 activity zones, establishes the concentric cortical patterns necessary for cell repair in wounded Xenopus oocytes.
Using oligodendrocyte-enriched brain organoids derived from trisomy 21 iPSCs, this study demonstrates that Down syndrome disrupts early brain development by impairing oligodendrocyte maturation and myelination, altering neural network activity, and causing transcriptomic dysregulation primarily during early neural and glial specification.
Using orbital TIRF microscopy, this study elucidates the dynamic relationship between adhesion site formation, retrograde translocation, and trail deposition of the malaria parasite surface proteins CSP and TRAP, revealing how their interplay drives sporozoite motility and provides visual evidence for outside-in signaling.
This study demonstrates that the conserved RNA recognition motif (RRM) of the translation initiation factor eIF4B is essential for the efficient nucleation and higher-order organization of stress granules, thereby coordinating the assembly of these condensates with effective translational repression during cellular stress.