276 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study utilizes kinetic mapping and ectopic tether localization assays in *Saccharomyces cerevisiae* to functionally assign specific Golgi-associated tethers—Sgm1, Imh1, and GARP—to distinct intra-Golgi and endosome-to-TGN recycling pathways, revealing a previously undocumented role for GARP in intra-Golgi trafficking.
This study demonstrates that ATG2A interacts with RAB1A-positive early secretory membranes to facilitate autophagosome biogenesis, revealing a critical role for RAB1A in lipid transport downstream of LC3B lipidation despite ARFGAP1 being dispensable for the process.
This study reveals that the copper-transporting ATPase ATP7B synergizes with the lysosomal exocytosis pathway to detoxify cadmium by trafficking to lysosomes and sequestering the metal, a mechanism distinct from ATP7A and essential for cellular resistance to cadmium-induced toxicity.
This secondary analysis of public data demonstrates that N-acetylcysteine provides partial, dose-dependent protection against heat stress-induced damage in skeletal muscle cells, with maximal efficacy at 2.0 mM showing a large effect size that supports its potential as an adjunct therapy for trauma-induced hypermetabolic states despite limited statistical significance due to small sample size.
This study demonstrates that adult *C. elegans* sensory neurons can regenerate their cilia and restore function following injury through a distinct mechanism involving the DAF-19, DLK-1, and CEBP-1 pathways, as well as modulatory signals from surrounding glia.
This study utilizes dark-field imaging to demonstrate that label-free, real-time monitoring of scattered light intensity can effectively track dynamic mitochondrial matrix volume changes and permeability transition in living cells, revealing distinct swelling responses to ion transport and ATP synthase subunit c deficiency.
This study reveals that mechanical signaling via RhoA maintains skeletal muscle stem cell quiescence by promoting SP1-mediated Dnmt3a expression to preserve DNA methylation programs, thereby preventing premature activation.
This study demonstrates that beef and bison semen can be successfully cryopreserved without the conventional 90-minute equilibration step when using a cholesterol-based extender, significantly reducing processing time while maintaining post-thaw sperm quality and fertility comparable to routine methods.
This study demonstrates that reduced expression and impaired dimerization of lamin A/C, rather than lamin B1, directly drive nuclear shape deformations in malignant cancer cells, with the more aggressive MDA-MB-231 cells exhibiting significantly higher sensitivity to these lamin A/C deficits.
This study demonstrates that in Drosophila nephrocytes, the Uvrag-containing PI3K complex generates PI(3)P to facilitate Hsc70-4-mediated removal of clathrin from endosomal membranes, a process essential for Rab7 compartment organization, HOPS recruitment, and successful lysosomal maturation.