361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This paper presents the results of a survey conducted among members of the Australian New Zealand Society for Extracellular Vesicles (ANZSEV) to characterize the composition, interests, and beliefs of its research community.
This study establishes the first comprehensive proteomic and phosphoproteomic database for mouse spermatogonial stem cells and progenitors, revealing that post-translational phosphorylation plays a more distinct regulatory role than protein expression in fate decisions and identifying key kinases whose inhibition impairs differentiation while linking specific proteins to testis phenotypes in knockout models.
This study identifies Netrin-1 as a critical guardian of human naive pluripotency that coordinates extracellular cues, intracellular signaling, and epigenetic remodeling to maintain the naive state and accelerate its acquisition in human embryonic stem cells.
This study demonstrates that senescent human myoblasts are selectively susceptible to reductive stress-induced cell death at high concentrations of antioxidant compounds, suggesting that the senolytic activity of many natural agents may stem from their ability to induce this specific type of stress.
This paper introduces HiExM, a scalable high-throughput expansion microscopy pipeline that overcomes the trade-off between spatial resolution and sample size to enable robust, quantitative profiling of individual organelle morphology and spatial heterogeneity across large cell populations.
This study establishes a quantitative biochemical mechanism for Stu2/XMAP215-family microtubule polymerases by demonstrating that they function as efficient, enzyme-like tubulin-shuttling antennas whose activity is governed by TOG domain binding kinetics, revealing a case of convergent evolution with actin polymerases.
This study utilizes single-cell transcriptomics across multiple vascular injury and atherosclerosis models to demonstrate that a rare, pre-existing "Primed" SMC compartment, rather than widespread phenotypic switching of contractile SMCs, serves as the dominant source of lesion cellularity through autonomous self-renewal.
This study reveals that TIAM1 regulates the interplay between centriole assembly and autolysosome cycling by ensuring proper PLK4 organization on centrioles and maintaining lysosomal homeostasis, thereby linking TIAM1 to centrosome quality-control pathways.
This study presents a semi-automated approach using mTmG transgenic mice and 3D confocal microscopy to efficiently reconstruct and analyze glomerular architecture, thereby overcoming the labor-intensive limitations of manual segmentation in studying kidney disease.
This study demonstrates that local acidosis promotes passive fatty acid uptake in endothelial cells, leading to lipid accumulation, endoplasmic reticulum stress, and oxidative damage that impair nitric oxide availability and cause vascular dysfunction.